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FLASH GENE
Symbol B3GNT2 contributors: mct - updated : 28-01-2014
HGNC name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
HGNC id 15629
Location 2p15      Physical location : 62.423.261 - 62.451.864
Synonym name
  • beta-1,3-N-acetylglucosaminyltransferase bGnT-1
  • beta-1,3-N-acetylglucosaminyltransferase bGnT-2
  • beta3gal-t5 gene
  • UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
  • beta-1,3-galactosyltransferase 7
  • Synonym symbol(s) B3GNT, B3GN-T1, B3GN-T2, B3GNT1, BETA3GNT, B3GALT7
    EC.number 2.4.1.149
    DNA
    TYPE functioning gene
    STRUCTURE 28.60 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text several transcripts differing by 5' and/or 3' utr
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2788 46 397 - Zhou
    - splicing 2710 46 397 ubiquitous Zhou
    - - splicing 1600 - 397 - Zhou
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Endocrineadrenal gland    
    Urinarybladder    
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three conserved cysteine residues
  • an N terminal cytoplasmic domain
  • a transmembrane segment,a stem region
  • a catalytic domain with five potential N glycosylation sites
  • HOMOLOGY
    interspecies homolog to murine B3gnt1
    intraspecies homolog to B3GNT3,B3GNT4
    Homologene
    FAMILY
  • beta-1,3-N-acetylglucosaminyltransferase family
  • glycosyltransferase 31 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • protein glycosylation
  • novel function for B3GNT2 glycosylation in maintaining expression of layer-specific vomeronasal receptors, as well as adhesion molecules required for proper accessory olfactory bulb (AOB) glomerular formation
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    biosynthesis of poly-N-acetylactosamine chains
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GCNT2 functions together with B3GNT2 to determine Poly-N-acetyllactosamine(PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • hyperactivation of lymphocytes occurred due to a lack of polylactosamine on receptor molecules in B3gnt2-/- mice