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FLASH GENE

Symbol

B3GNT2

contributors: mct - updated : 28-01-2014

HGNC name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
HGNC id	15629

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach         Endocrine adrenal gland         Urinary bladder           kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three conserved cysteine residues
	an N terminal cytoplasmic domain
	a transmembrane segment,a stem region
	a catalytic domain with five potential N glycosylation sites

HOMOLOGY

interspecies

homolog to murine B3gnt1

intraspecies

homolog to B3GNT3,B3GNT4

Homologene

FAMILY	beta-1,3-N-acetylglucosaminyltransferase family
	glycosyltransferase 31 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II transmembrane protein

basic FUNCTION	protein glycosylation
	novel function for B3GNT2 glycosylation in maintaining expression of layer-specific vomeronasal receptors, as well as adhesion molecules required for proper accessory olfactory bulb (AOB) glomerular formation

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

biosynthesis of poly-N-acetylactosamine chains

a component

INTERACTION

DNA

RNA

small molecule

protein

GCNT2 functions together with B3GNT2 to determine Poly-N-acetyllactosamine(PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

hyperactivation of lymphocytes occurred due to a lack of polylactosamine on receptor molecules in B3gnt2-/- mice