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FLASH GENE
Symbol VAMP3 contributors: mct - updated : 28-03-2018
HGNC name vesicle-associated membrane protein 3 (cellubrevin)
HGNC id 12644
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amphipathic helix which may participate in coiled coil interactions
  • a C terminal hydrophobic domain predicted to serve as a membrane anchor
    • HOMOLOGY
    Homologene
    FAMILY
  • synaptobrevin family
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • v-SNARE that resides in recycling endosomes and endosome-derived transport vesicles
  • VAMP3 and VAMP7 colocalize with the major myelin proteolipid protein (PLP1) in recycling endosomes and late endosomes/lysosomes, respectively
    • basic FUNCTION
  • soluble N ethylmaleimide-sensitive factor-attachment protein receptor, SNARE protein
  • associated with the early endosome, involved in regulating membrane traffic
  • VAMP3 and AP1B1 cooperate in basolateral membrane trafficking
  • implicated in recycling of transferrin receptors, secretion of alpha-granules in platelets, and membrane trafficking during cell migration
  • transport vesicles containing VAMP3 have distinct membrane fusion kinetics with domains of the plasma membrane that present different t-SNARE proteins
  • SNARE protein that mediates exocytosis, in cell migration and integrin trafficking
  • VAMP3-dependent integrin trafficking is crucial in cell migration and cell adhesion to laminin, and VAMP3-mediated integrin trafficking is critical in cell migration and cell adhesion to laminin
  • with other VAMPs, has differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs
  • involvement of VAMP3/cellubrevin and VAMP7/TI-VAMP in myelin membrane trafficking
  • regulates podosome organisation in macrophages and together with STX4/SNAP23 mediates adhesion, cell spreading and persistent migration
  • platelets are capable of a range of endocytosis steps, with VAMP3 being pivotal in these processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
  • potential new integrin trafficking pathway in which endocytosed integrins are transported from VAMP3-containing recycling endosomes to STX6-containing trans-Golgi network before being recycled to the plasma membrane
    • a component
  • complex between proteins on vesicle and target membranes
  • VAMP-3 and VAMP-8 forming SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BCAP29
  • with SNAP23 and STX12, have a role in the trafficking of MMP during degradation of ECM substrates and subsequent cellular invasion
  • regulates podosome organisation in macrophages and together with STX4/SNAP23 mediates adhesion, cell spreading and persistent migration
  • RNF130 ubiquitin ligases play a novel role in regulating recycling endosome trafficking via ubiquitylation of the VAMP3 SNARE protein
  • PI4K2A is a binding partner of vesicle-associated membrane protein 3 (VAMP3), a small R-SNARE involved in recycling and retrograde transport, and the two proteins co-reside on tubulo-vesicular endosomes
  • small GTPase RAB8A interacts with VAMP3 to regulate the delivery of recycling T-cell receptors to the immune synapse
  • VAMP3 interacts with SLC12A1 and mediates its constitutive exocytic delivery to the apical surface, and VAMP3 is required for normal SLC12A1 expression, renal function, and blood pressure
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    silencing inhibits cell adhesion to laminin and effectively reduced cell motility
    constitutional     --over  
    protects cardiac glucose metabolism under conditions of impaired insulin sensitivity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Vamp3-/- mice had less platelet-associated Fg, indicating a defect in Fg uptake/storage