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FLASH GENE
Symbol GTF3C1 contributors: mct/ - updated : 22-03-2006
HGNC name general transcription factor IIIC, polypeptide 1, alpha 220kDa
HGNC id 4664
PROTEIN
PHYSICAL PROPERTIES acid ,basic
STRUCTURE
motifs/domains
  • containing acidic and basic region, tetratricopeptide repeat*
  • a TOR signaling motif that facilitates its association with MTOR
    • secondary structure
  • a helix-loop-helix domain
    • HOMOLOGY
    interspecies ortholog to rattus Rn11288
    Homologene
    FAMILY
  • TFIIIC subunit 1 family
  • GTF3C family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in recruitment of both GTF3B and RNA Pol3
  • component of TFIIIC initiating transcription complex assembly on tRNA and required for transcription of 5s rRNA and other stable nuclear and cytoplasmic RNAs
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alpha subunit of transcription factor TFIIIC
    • INTERACTION
    DNA binding to B-box promoter elements
    RNA
    small molecule
    protein
  • interaction of MTOR with MAF1 and GTF3C1 in nuclei
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS