Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GTF3C1 contributors: mct/ - updated : 22-03-2006
HGNC name general transcription factor IIIC, polypeptide 1, alpha 220kDa
HGNC id 4664
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunethymus   highly
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid ,basic
STRUCTURE
motifs/domains
  • containing acidic and basic region, tetratricopeptide repeat*
  • a TOR signaling motif that facilitates its association with MTOR
  • secondary structure
  • a helix-loop-helix domain
  • HOMOLOGY
    interspecies ortholog to rattus Rn11288
    Homologene
    FAMILY
  • TFIIIC subunit 1 family
  • GTF3C family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in recruitment of both GTF3B and RNA Pol3
  • component of TFIIIC initiating transcription complex assembly on tRNA and required for transcription of 5s rRNA and other stable nuclear and cytoplasmic RNAs
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alpha subunit of transcription factor TFIIIC
  • INTERACTION
    DNA binding to B-box promoter elements
    RNA
    small molecule
    protein
  • interaction of MTOR with MAF1 and GTF3C1 in nuclei
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS