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FLASH GENE

Symbol

GTF3C1

contributors: mct/ - updated : 22-03-2006

HGNC name	general transcription factor IIIC, polypeptide 1, alpha 220kDa
HGNC id	4664

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p12.1      Physical location : 27.471.934 - 27.561.251
Synonym name	general transcription factor IIIC, polypeptide 1 (alpha subunit)
	TF3C-alpha
	TFIIIC box B-binding subunit
Synonym symbol(s)	TFIIIC, TFIIIC220, TFIIICalpha, DKFZp686A111

DNA

TYPE	functioning gene
STRUCTURE	89.32 kb     37 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	two isoforms GTF3C102 and GTF3C63

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001520 37 - 7124 NP_001511 - 2109 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Lymphoid/Immune thymus       highly

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid ,basic
STRUCTURE

motifs/domains	containing acidic and basic region, tetratricopeptide repeat*
	a TOR signaling motif that facilitates its association with MTOR

secondary structure

a helix-loop-helix domain

HOMOLOGY

interspecies

ortholog to rattus Rn11288

Homologene

FAMILY	TFIIIC subunit 1 family
	GTF3C family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in recruitment of both GTF3B and RNA Pol3
	component of TFIIIC initiating transcription complex assembly on tRNA and required for transcription of 5s rRNA and other stable nuclear and cytoplasmic RNAs

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

alpha subunit of transcription factor TFIIIC

INTERACTION

DNA	binding to B-box promoter elements

RNA

small molecule

protein

interaction of MTOR with MAF1 and GTF3C1 in nuclei

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS