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FLASH GENE
Symbol PLAU contributors: mct - updated : 12-06-2017
HGNC name plasminogen activator, urokinase
HGNC id 9052
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine-rich kringle domain
  • one EGF-like domain
    • HOMOLOGY
    Homologene
    FAMILY peptidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • plasminogen activator, urokinase serine protease, involved in plasminogen activation to plasmin
  • playing a role in the regulation of monocyte/macrophage functions, such as that occurring in inflammatory reactions
  • critical role for PLAU in Treg suppressor function
  • IL6, JUN, and PLAU may be involved in development of neuropathic pain
  • is involved in cell migration, proliferation and tissue remodeling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SP100 interacts with the ETS1 transcription factor, reduces ETS1-DNA binding and inhibits ETS1 transcriptional activity on the MMP1 and PLAU promoters
  • SERPINB2 is a potent inhibitor of urokinase-type plasminogen activator (PLAU) and also acts as a multifunctional protein
  • BRMS1 recruits HDAC1 to the NF-kappaB binding site of the PLAU promoter, modulates histone acetylation of RELA on the PLAU promoter, leading to reduced NF-kappaB binding activity on its consensus sequence, and reduced transactivation of PLAU expression
  • mediates Treg suppressor function via STAT5 and ERK signaling pathways
  • HMGA1 has a direct role in regulating the transcription of PLAU and SERPINE1 which may constitute an important mechanism by which HMGA1 promotes cancer progression
  • MMD-dependent secretion of a protease, PLAU, prevents anoikis and initiates autocrine activation of a PLAU receptor/signal transducer
  • activation of STING inhibits cancer cell migration and invasion by suppressing PLAU
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    could suppress tumor growth
    Susceptibility
  • to Alzheimer disease
  • to myocardial infarction (MI)
    • Variant & Polymorphism other
  • polymorphism increasing the risk of Alzheimer disease
  • rs4065 might be a previously unknown genetic risk factor for MI
    • Candidate gene
    Marker
  • can be a diagnostic and prognostic biomarker in in head and neck squamous cell carcinoma (HNSCC)
    • Therapy target
    ANIMAL & CELL MODELS