Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLAU contributors: mct - updated : 12-06-2017
HGNC name plasminogen activator, urokinase
HGNC id 9052
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2680 - 414 - 2014 24549574
11 - 2395 - 431 - 2014 24549574
10 - 2315 - 345 - 2014 24549574
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrinepancreas   highly
Nervousbrain    
Respiratorylung   highly
 respiratory tractlarynx   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion urine
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine-rich kringle domain
  • one EGF-like domain
  • HOMOLOGY
    Homologene
    FAMILY peptidase family S1
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • plasminogen activator, urokinase serine protease, involved in plasminogen activation to plasmin
  • playing a role in the regulation of monocyte/macrophage functions, such as that occurring in inflammatory reactions
  • critical role for PLAU in Treg suppressor function
  • IL6, JUN, and PLAU may be involved in development of neuropathic pain
  • is involved in cell migration, proliferation and tissue remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SP100 interacts with the ETS1 transcription factor, reduces ETS1-DNA binding and inhibits ETS1 transcriptional activity on the MMP1 and PLAU promoters
  • SERPINB2 is a potent inhibitor of urokinase-type plasminogen activator (PLAU) and also acts as a multifunctional protein
  • BRMS1 recruits HDAC1 to the NF-kappaB binding site of the PLAU promoter, modulates histone acetylation of RELA on the PLAU promoter, leading to reduced NF-kappaB binding activity on its consensus sequence, and reduced transactivation of PLAU expression
  • mediates Treg suppressor function via STAT5 and ERK signaling pathways
  • HMGA1 has a direct role in regulating the transcription of PLAU and SERPINE1 which may constitute an important mechanism by which HMGA1 promotes cancer progression
  • MMD-dependent secretion of a protease, PLAU, prevents anoikis and initiates autocrine activation of a PLAU receptor/signal transducer
  • activation of STING inhibits cancer cell migration and invasion by suppressing PLAU
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    could suppress tumor growth
    Susceptibility
  • to Alzheimer disease
  • to myocardial infarction (MI)
  • Variant & Polymorphism other
  • polymorphism increasing the risk of Alzheimer disease
  • rs4065 might be a previously unknown genetic risk factor for MI
  • Candidate gene
    Marker
  • can be a diagnostic and prognostic biomarker in in head and neck squamous cell carcinoma (HNSCC)
  • Therapy target
    ANIMAL & CELL MODELS