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FLASH GENE
Symbol FCER2 contributors: mct - updated : 16-05-2022
HGNC name Fc fragment of IgE, low affinity II, receptor for (CD23A)
HGNC id 3612
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a lectin "head," N-terminal "stalk," and C-terminal "tail" in the extracellular sequence
  • a leucine zipper
  • a transmembrane domain
  • a short cytoplasmic tail
  • a C-terminal lectin-like domain that resembles C-type carbohydrate-recognition domains (CRDs) found in many glycan-binding receptors
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • having essential roles in the regulation of Ige production and in the differentiation of B-cells (it is a B-cell-specific antigen)
  • low affinity receptor for IgE and in B cells has been proposed to play a role in the regulation of IgE synthesis
  • FCER2-mediated signal transduction pathways in human B cells and human monocytes are different
  • low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses (
  • FCER2-bound IgE augments and dominates recall responses through naive B cells
  • when expressed on B cells, FCER2 appears to play a role in regulation of IgE synthesis
  • role for FCER2 likely in many species as a receptor for potentially pathogenic microorganisms as well as IgE
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DOCK10 negatively regulates membrane FCER2 expression, and negative regulation of FCER2 expression by DOCK10 could play a role in B cell maturation and function
  • FCER2-mediated IgE transcytosis in the hair cells may play a critical role in initiating inflammation in the inner ear
  • cell & other
    REGULATION
    Other cleaved by a disintegrin and metalloproteinase 10 (ADAM10) and this cleavage influences the ability of FCER2 to regulate IgE
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in follicular lymphoma of the inguinal region
    Susceptibility to atopy
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    could be targets for therapeutic intervention in allergic disease
    ANIMAL & CELL MODELS