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FLASH GENE
Symbol FCER2 contributors: mct - updated : 16-05-2022
HGNC name Fc fragment of IgE, low affinity II, receptor for (CD23A)
HGNC id 3612
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
 tonsils    
Respiratoryrespiratory tractlarynx   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil Homo sapiens
Blood/Hematopoieticmonocyte Homo sapiens
Lymphoid/Immunedendritic cell Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a lectin "head," N-terminal "stalk," and C-terminal "tail" in the extracellular sequence
  • a leucine zipper
  • a transmembrane domain
  • a short cytoplasmic tail
  • a C-terminal lectin-like domain that resembles C-type carbohydrate-recognition domains (CRDs) found in many glycan-binding receptors
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • having essential roles in the regulation of Ige production and in the differentiation of B-cells (it is a B-cell-specific antigen)
  • low affinity receptor for IgE and in B cells has been proposed to play a role in the regulation of IgE synthesis
  • FCER2-mediated signal transduction pathways in human B cells and human monocytes are different
  • low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses (
  • FCER2-bound IgE augments and dominates recall responses through naive B cells
  • when expressed on B cells, FCER2 appears to play a role in regulation of IgE synthesis
  • role for FCER2 likely in many species as a receptor for potentially pathogenic microorganisms as well as IgE
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DOCK10 negatively regulates membrane FCER2 expression, and negative regulation of FCER2 expression by DOCK10 could play a role in B cell maturation and function
  • FCER2-mediated IgE transcytosis in the hair cells may play a critical role in initiating inflammation in the inner ear
  • cell & other
    REGULATION
    Other cleaved by a disintegrin and metalloproteinase 10 (ADAM10) and this cleavage influences the ability of FCER2 to regulate IgE
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in follicular lymphoma of the inguinal region
    Susceptibility to atopy
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    could be targets for therapeutic intervention in allergic disease
    ANIMAL & CELL MODELS