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FLASH GENE

Symbol

FCER2

contributors: mct - updated : 16-05-2022

HGNC name	Fc fragment of IgE, low affinity II, receptor for (CD23A)
HGNC id	3612

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.2      Physical location : 7.753.642 - 7.767.032
Synonym name	cell differentiation antigen CD23 (p45), 50-45kDa, low affinity Fc epsilon RII-IgE receptor, identified by monoclonal antibodies BLAST-2, MHM6
	C-type lectin domain family 4, member J
	CD23 antigen
Synonym symbol(s)	CD23, FCE2, CD23A, CLEC4J, IGEBF, BLAST-2

DNA

TYPE	functioning gene
STRUCTURE	13.36 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002002 11 - 1620 NP_001993 37 321 - 2021 34075727 NM_001220500 11 - 1585 NP_001207429 - 321 - 2021 34075727 NM_001207019 10 - 1426 NP_001193948 - 320 - 2021 34075727

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           spleen           thymus           tonsils         Respiratory respiratory tract larynx

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic eosinophil Homo sapiens Blood/Hematopoietic monocyte Homo sapiens Lymphoid/Immune dendritic cell Homo sapiens Lymphoid/Immune macrophage Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a lectin "head," N-terminal "stalk," and C-terminal "tail" in the extracellular sequence
	a leucine zipper
	a transmembrane domain
	a short cytoplasmic tail
	a C-terminal lectin-like domain that resembles C-type carbohydrate-recognition domains (CRDs) found in many glycan-binding receptors

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense , antigen

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	having essential roles in the regulation of Ige production and in the differentiation of B-cells (it is a B-cell-specific antigen)
	low affinity receptor for IgE and in B cells has been proposed to play a role in the regulation of IgE synthesis
	FCER2-mediated signal transduction pathways in human B cells and human monocytes are different
	low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses (
	FCER2-bound IgE augments and dominates recall responses through naive B cells
	when expressed on B cells, FCER2 appears to play a role in regulation of IgE synthesis
	role for FCER2 likely in many species as a receptor for potentially pathogenic microorganisms as well as IgE

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	DOCK10 negatively regulates membrane FCER2 expression, and negative regulation of FCER2 expression by DOCK10 could play a role in B cell maturation and function
	FCER2-mediated IgE transcytosis in the hair cells may play a critical role in initiating inflammation in the inner ear

cell & other

REGULATION

Other	cleaved by a disintegrin and metalloproteinase 10 (ADAM10) and this cleavage influences the ability of FCER2 to regulate IgE

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in follicular lymphoma of the inguinal region

Susceptibility

to atopy

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed allergy asthm   could be targets for therapeutic intervention in allergic disease

ANIMAL & CELL MODELS