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FLASH GENE

Symbol

MRC1

contributors: mct/npt - updated : 20-11-2009

HGNC name	mannose receptor, C type 1
HGNC id	7228

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	8 C-type lectin domains
	a fibronectin type-II domain
	a ricin b-type lectin domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 membrane receptor

basic FUNCTION

mediating the endocytosis of glycoproteins by macrophages

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with MCM6 (specific MRC1-binding protein) (Komata 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LPRS

Susceptibility

to leprosy

Variant & Polymorphism other	significant association of the glycine allele of the G396S polymorphism with leprosy and multibacillary leprosy (Alter 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS