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FLASH GENE
Symbol MRC1 contributors: mct/npt - updated : 20-11-2009
HGNC name mannose receptor, C type 1
HGNC id 7228
Corresponding disease
LPRS leprosy, susceptibility locus 1
Location 10p12.33      Physical location : 17.851.361 - 18.200.090
Synonym name
  • macrophage mannose receptor
  • C-type lectin domain family 13 member D
  • CD206 antigen
    • Synonym symbol(s) RP11-457D2.1, CLEC13D, CD206, MMR
    DNA
    TYPE functioning gene
    STRUCTURE 101.82 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 5171 - 1456 - Kim (1992)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 8 C-type lectin domains
  • a fibronectin type-II domain
  • a ricin b-type lectin domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane receptor
    basic FUNCTION
  • mediating the endocytosis of glycoproteins by macrophages
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MCM6 (specific MRC1-binding protein) (Komata 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LPRS
    Susceptibility to leprosy
    Variant & Polymorphism other significant association of the glycine allele of the G396S polymorphism with leprosy and multibacillary leprosy (Alter 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS