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FLASH GENE

Symbol

MRC1

contributors: mct/npt - updated : 20-11-2009

HGNC name	mannose receptor, C type 1
HGNC id	7228

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	101.82 kb     30 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002438 30 - 5171 NP_002429 - 1456 - Kim (1992)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	8 C-type lectin domains
	a fibronectin type-II domain
	a ricin b-type lectin domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 membrane receptor

basic FUNCTION

mediating the endocytosis of glycoproteins by macrophages

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with MCM6 (specific MRC1-binding protein) (Komata 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LPRS

Susceptibility

to leprosy

Variant & Polymorphism other	significant association of the glycine allele of the G396S polymorphism with leprosy and multibacillary leprosy (Alter 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS