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FLASH GENE
Symbol MOV10L1 contributors: mct - updated : 05-07-2022
HGNC name Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
HGNC id 7201
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Mov10
Homologene
FAMILY
  • DNA2/NAM7 helicase family
  • SDE3 subfamily
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text found in small quantities in the nucleus
    basic FUNCTION
  • required for rapid turnover of mRNAs containing a premature translational termination codon
  • may play a role in male germ cell development
  • putative germline-specific RNA helicase (Lovasco 2010)
  • may be functioning as a key component of a safeguard mechanism for the genetic information in male germ cells of mammals
  • MOV10L1 acts upstream of Piwi proteins in the primary processing of pachytene piRNAs, suggesting that, distinct from pre-pachytene piRNAs, pachytene piRNAs fulfill a unique function in maintaining post-meiotic genome integrity
  • testis-specific MOV10L1 is essential for spermatogenesis and PIWI-interacting RNAs biogenesis, whereas MOV10 is ubiquitous and multifunctional
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MOV10L1 expression is sensitive to TAF4B level, linking TAF4B to the posttranscriptional control of ovarian gene expression
  • interacts with the Piwi proteins MILI and MIWI and also interacts with HSPA2, a testis-enriched chaperone expressed in pachytene spermatocytes and also essential for male fertility
  • MOV10L1 selectively binds piRNA precursor transcripts and is essential for the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins
  • RG4 (RNA G-Quadruplex) unwinding by MOV10L1 facilitates the cleavage of this specific RNA structure by an endonuclease
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF73
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Primary spermatocytes of Mov10l1(-/-) mice show activation of LTR and LINE-1 retrotransposons, followed by cell death, causing male infertility and a complete block of spermatogenesis at early prophase of meiosis I
  • Mov10l1 mutant mice exhibit meiotic arrest and male sterility