basic FUNCTION
| required for rapid turnover of mRNAs containing a premature translational termination codon |
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may play a role in male germ cell development |
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putative germline-specific RNA helicase (Lovasco 2010) |
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may be functioning as a key component of a safeguard mechanism for the genetic information in male germ cells of mammals |
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MOV10L1 acts upstream of Piwi proteins in the primary processing of pachytene piRNAs, suggesting that, distinct from pre-pachytene piRNAs, pachytene piRNAs fulfill a unique function in maintaining post-meiotic genome integrity |
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testis-specific MOV10L1 is essential for spermatogenesis and PIWI-interacting RNAs biogenesis, whereas MOV10 is ubiquitous and multifunctional |