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FLASH GENE
Symbol PCBP4 contributors: mct/npt - updated : 26-01-2013
HGNC name poly(rC) binding protein 4
HGNC id 8652
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA binding protein with three K homology (KH) motifs, playing an important role in the regulation of translation of eukaryotic mRNA
    • HOMOLOGY
    Homologene
    FAMILY
  • poly(C)-binding protein family
  • KH-domain protein subfamily
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • involved in the posttranscriptional control
  • can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M
  • its expression can inhibit proliferation and tumorigenesis of lung cancer cells, by delaying the progression of the cell cycle
  • regulates both basal and stress-induced CDKN1A expression through binding CDKN1A 3prime-UTR and modulating CDKN1A mRNA stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCBP4 expression decreases cyclin-dependent kinase inhibitor CDKN1A induction in response to DNA damage
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS