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FLASH GENE
Symbol PCBP4 contributors: mct/npt - updated : 26-01-2013
HGNC name poly(rC) binding protein 4
HGNC id 8652
Location 3p21.2      Physical location : 51.991.471 - 52.001.482
Synonym name
  • LYST-interacting protein
  • RNA binding protein MCG10
  • alphaCP-4 protein
  • Synonym symbol(s) LIP4, MCG10, alpha-CP4, hnRNP E4, CBP
    DNA
    TYPE functioning gene
    STRUCTURE 10.01 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2623 - 424 - 2008 17973258
    11 - 2458 - 369 - 2008 17973258
    13 - 2040 - 403 - 2008 17973258
    13 - 1962 - 360 - 2008 17973258
    14 - 2188 - 403 - 2008 17973258
    13 - 1982 - 403 - 2008 17973258
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrain   highly
    Reproductivemale systemtestis   
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RNA binding protein with three K homology (KH) motifs, playing an important role in the regulation of translation of eukaryotic mRNA
  • HOMOLOGY
    Homologene
    FAMILY
  • poly(C)-binding protein family
  • KH-domain protein subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • involved in the posttranscriptional control
  • can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M
  • its expression can inhibit proliferation and tumorigenesis of lung cancer cells, by delaying the progression of the cell cycle
  • regulates both basal and stress-induced CDKN1A expression through binding CDKN1A 3prime-UTR and modulating CDKN1A mRNA stability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCBP4 expression decreases cyclin-dependent kinase inhibitor CDKN1A induction in response to DNA damage
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS