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FLASH GENE
Symbol PCBP4 contributors: mct/npt - updated : 26-01-2013
HGNC name poly(rC) binding protein 4
HGNC id 8652
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2623 - 424 - 2008 17973258
11 - 2458 - 369 - 2008 17973258
13 - 2040 - 403 - 2008 17973258
13 - 1962 - 360 - 2008 17973258
14 - 2188 - 403 - 2008 17973258
13 - 1982 - 403 - 2008 17973258
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Nervousbrain   highly
Reproductivemale systemtestis   
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA binding protein with three K homology (KH) motifs, playing an important role in the regulation of translation of eukaryotic mRNA
  • HOMOLOGY
    Homologene
    FAMILY
  • poly(C)-binding protein family
  • KH-domain protein subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • involved in the posttranscriptional control
  • can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M
  • its expression can inhibit proliferation and tumorigenesis of lung cancer cells, by delaying the progression of the cell cycle
  • regulates both basal and stress-induced CDKN1A expression through binding CDKN1A 3prime-UTR and modulating CDKN1A mRNA stability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCBP4 expression decreases cyclin-dependent kinase inhibitor CDKN1A induction in response to DNA damage
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS