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FLASH GENE
Symbol GPRC5C contributors: - updated : 25-07-2006
HGNC name G protein-coupled receptor, family C, group 5, member C
HGNC id 13309
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a signal peptide
  • seven transmembrane alpha helices
  • eight hydrophobic segments
  • a short aminoterminal domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Gprc5c (88.2pc)
    ortholog to murine Gprc5c (89.6pc)
    Homologene
    FAMILY
  • orphan G protein-coupled receptor, family C, group 1, member 5C
  • G-protein coupled receptor 3 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localized in the plasma membrane and perinuclear vesicles
  • cell membrane (multi-pass membrane protein)
  • cytoplasmic vesicle membrane (multi-pass membrane protein)
    • basic FUNCTION
  • acting as a metabotropic glutamate, GABA-B-like receptor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by all-trans retinoic acid (ATRA)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS