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FLASH GENE
Symbol GPRC5C contributors: - updated : 25-07-2006
HGNC name G protein-coupled receptor, family C, group 5, member C
HGNC id 13309
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2389 52.8 486 - Robbins
  • 4 exons
  • - splicing 1836 49.3 453 - Robbins
  • 4 exons
  • differing in the 5' UTR and coding region compared to variant 1
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   predominantly
    Endocrinepancreas   moderately
    Nervousbrain   moderately
     brainhindbraincerebellum  
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a signal peptide
  • seven transmembrane alpha helices
  • eight hydrophobic segments
  • a short aminoterminal domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Gprc5c (88.2pc)
    ortholog to murine Gprc5c (89.6pc)
    Homologene
    FAMILY
  • orphan G protein-coupled receptor, family C, group 1, member 5C
  • G-protein coupled receptor 3 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localized in the plasma membrane and perinuclear vesicles
  • cell membrane (multi-pass membrane protein)
  • cytoplasmic vesicle membrane (multi-pass membrane protein)
  • basic FUNCTION
  • acting as a metabotropic glutamate, GABA-B-like receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by all-trans retinoic acid (ATRA)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS