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FLASH GENE

Symbol

GPRC5C

contributors: - updated : 25-07-2006

HGNC name	G protein-coupled receptor, family C, group 5, member C
HGNC id	13309

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive stomach       predominantly Endocrine pancreas       moderately Nervous brain       moderately   brain hindbrain cerebellum     Reproductive female system uterus cervix   highly   male system testis     highly Respiratory respiratory tract trachea     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	a signal peptide
	seven transmembrane alpha helices
	eight hydrophobic segments
	a short aminoterminal domain

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus Gprc5c (88.2pc)
	ortholog to murine Gprc5c (89.6pc)

Homologene

FAMILY	orphan G protein-coupled receptor, family C, group 1, member 5C
	G-protein coupled receptor 3 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular,cytoplasm,cytosolic,vesicle
text	localized in the plasma membrane and perinuclear vesicles
	cell membrane (multi-pass membrane protein)
	cytoplasmic vesicle membrane (multi-pass membrane protein)

basic FUNCTION

acting as a metabotropic glutamate, GABA-B-like receptor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

neurotransmission , signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

all-trans retinoic acid (ATRA)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS