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FLASH GENE
Symbol P2RX6 contributors: mct/npt - updated : 18/09/2008
HGNC name purinergic receptor P2X, ligand-gated ion channel, 6
HGNC id 8538
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two short intracellular domains
  • two transmembrane spanning segments
  • a large extracellular loop
    • mono polymer trimer
    HOMOLOGY
    Homologene
    FAMILY
  • P2X receptor family
    • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    text associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells
    basic FUNCTION
  • cation-selective channels activated by extracellular ATP
  • purinoceptor P2XM, ionotropic class
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • associated with VE-cadherin at HUVEC adherens junctions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS