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FLASH GENE
Symbol P2RX6 contributors: mct/npt - updated : 18/09/2008
HGNC name purinergic receptor P2X, ligand-gated ion channel, 6
HGNC id 8538
Location 22q11.21      Physical location : 21.369.441 - 21.382.302
Synonym name
  • purinergic receptor P2X-like 2, orphan receptor
  • purinergic receptor P2X-like 1, orphan receptor
  • purinoceptor P2X6
  • skeletal muscle-expressed P2X
  • ATP receptor
  • Synonym symbol(s) P2RXL2, MGC129625, P2RXL1, P2X6, P2XM, P2RXM
    DNA
    TYPE functioning gene
    STRUCTURE 12.84 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2745 - 441 - Barrera (2005)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbrain    
    Reproductivefemale systemplacenta   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two short intracellular domains
  • two transmembrane spanning segments
  • a large extracellular loop
  • mono polymer trimer
    HOMOLOGY
    Homologene
    FAMILY
  • P2X receptor family
  • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    text associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells
    basic FUNCTION
  • cation-selective channels activated by extracellular ATP
  • purinoceptor P2XM, ionotropic class
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • associated with VE-cadherin at HUVEC adherens junctions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS