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FLASH GENE
Symbol P2RX6 contributors: mct/npt - updated : 18/09/2008
HGNC name purinergic receptor P2X, ligand-gated ion channel, 6
HGNC id 8538
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2745 - 441 - Barrera (2005)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Nervousbrain    
Reproductivefemale systemplacenta   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two short intracellular domains
  • two transmembrane spanning segments
  • a large extracellular loop
  • mono polymer trimer
    HOMOLOGY
    Homologene
    FAMILY
  • P2X receptor family
  • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    text associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells
    basic FUNCTION
  • cation-selective channels activated by extracellular ATP
  • purinoceptor P2XM, ionotropic class
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • associated with VE-cadherin at HUVEC adherens junctions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS