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FLASH GENE
Symbol LPAR2 contributors: mct/npt - updated : 12-12-2014
HGNC name lysophosphatidic acid receptor 2
HGNC id 3168
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domains (7TM)
  • potential N glycosylation sites in the N terminus
  • potential serine/threonine kinase phosphorylation sites in the intracellular portion
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Edg4
    ortholog to Drosophila mbf1
    ortholog to C.elegans H21P03.1
    Homologene
    FAMILY
  • family I of the G protein coupled receptor
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • functioning as a lysophosphatidic acid (LPA) receptor and contributing to Ca2+ mobilization
  • activating phospholipase C
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with LPAR2 and regulates the ability of LPAR2 to activate Erk and RHOA
  • PDZ-mediated interaction of SLC9A3R2 and LPAR2, a cellular event implicated in CFTR channel regulation
    • cell & other
  • lipid, lysophosphatidic acid (LPA)
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS