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FLASH GENE

Symbol

LPAR2

contributors: mct/npt - updated : 12-12-2014

HGNC name	lysophosphatidic acid receptor 2
HGNC id	3168

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	one or two transcripts

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 8000 - - peripheral blood leukocytes,thymus,spleen,all tumors An variant 2a - - 1800 42.6 382 leukocytes,testis,prostate,pancreas,adherent cancer cell lines An variant 2b 3 - 1803 - 351 - Bandoh, Lin (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine parathyroid       highly Nervous brain         Reproductive male system testis     highly

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument hair follicle cell

cell lineage
cell lines	ovarian cancer cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane domains (7TM)
	potential N glycosylation sites in the N terminus
	potential serine/threonine kinase phosphorylation sites in the intracellular portion

conjugated

GlycoP , PhosphoP

HOMOLOGY

interspecies	ortholog to murine Edg4
	ortholog to Drosophila mbf1
	ortholog to C.elegans H21P03.1

Homologene

FAMILY

family I of the G protein coupled receptor

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	functioning as a lysophosphatidic acid (LPA) receptor and contributing to Ca2+ mobilization
	activating phospholipase C

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts directly with LPAR2 and regulates the ability of LPAR2 to activate Erk and RHOA
	PDZ-mediated interaction of SLC9A3R2 and LPAR2, a cellular event implicated in CFTR channel regulation

cell & other

lipid, lysophosphatidic acid (LPA)

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS