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FLASH GENE
Symbol LPAR2 contributors: mct/npt - updated : 12-12-2014
HGNC name lysophosphatidic acid receptor 2
HGNC id 3168
Location 19p12      Physical location : 19.734.467 - 19.739.039
Synonym name
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
  • lysophosphatidic acid receptor Edg-4
  • G protein-coupled receptor
  • Synonym symbol(s) LPA2, EDG-4, EDG4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 4.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text one or two transcripts
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 8000 - - peripheral blood leukocytes,thymus,spleen,all tumors An
    - - 1800 42.6 382 leukocytes,testis,prostate,pancreas,adherent cancer cell lines An
    3 - 1803 - 351 - Bandoh, Lin (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineparathyroid   highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    cell lineage
    cell lines ovarian cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane domains (7TM)
  • potential N glycosylation sites in the N terminus
  • potential serine/threonine kinase phosphorylation sites in the intracellular portion
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Edg4
    ortholog to Drosophila mbf1
    ortholog to C.elegans H21P03.1
    Homologene
    FAMILY
  • family I of the G protein coupled receptor
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • functioning as a lysophosphatidic acid (LPA) receptor and contributing to Ca2+ mobilization
  • activating phospholipase C
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with LPAR2 and regulates the ability of LPAR2 to activate Erk and RHOA
  • PDZ-mediated interaction of SLC9A3R2 and LPAR2, a cellular event implicated in CFTR channel regulation
  • cell & other
  • lipid, lysophosphatidic acid (LPA)
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS