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FLASH GENE

Symbol

TIMM17B

contributors: - updated : 03-05-2005

HGNC name	translocase of inner mitochondrial membrane 17 homolog B (yeast)
HGNC id	17310

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       lowly Endocrine pancreas       lowly Nervous brain       moderately Reproductive male system prostate     moderately Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta lowly

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

four hydrophobic membrane-spanning segments

HOMOLOGY

interspecies	homolog to murine Timm17b
	homolog to Drosophile Tim17b1
	homolog to C.elegans E04A4.5

intraspecies

homolog to TIMM17A

Homologene

FAMILY

TIM17/TIM22/TIM23 family

CATEGORY

enzyme , transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner

basic FUNCTION

translocating nuclear-encoded proteins into the mitochondrion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

mitochondrial transport

PATHWAY

metabolism

signaling

a component

forming part of the TIM23 receptor complex consisting of at least three different proteins TIM17, TIM23 and TIM44 (forming 2 distinct 110-kD complexes)

INTERACTION

DNA

RNA

small molecule

protein	TIMM17A
	TIMM17B
	TIMM23
	TIMM44

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS