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FLASH GENE
Symbol GRAP2 contributors: mct - updated : 30-08-2017
HGNC name GRB2-related adaptor protein 2
HGNC id 4563
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines leukemia cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal SH3 domain followed by a SH2 domain
  • an unique proline/glutamine-rich sequence od 120 AA between SH2 and the C terminal SH3 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • GRB2/sem-5/DRK family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • coupling tyrosine kinase to the RAS pathway
  • adaptor protein in the CD28 mediated costimulatory pathway in T cells
  • recruiting cytosolic signal-transducing molecules to the activated receptor tyrosine kinases
  • critical adaptor for CD3 signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text required for T cell development
    PATHWAY
    metabolism
    signaling signal transduction
    LCP2/GRAP2/NCK1 adaptor protein pathway, implicated in regulation of the actin cytoskeleton by BCR-ABL kinase (Preisinger 2010)
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CKIT
  • EPOR binding
  • CD28 and other signaling proteins, LCP2 like (SLP-76), GNB2L1 (RACK1), growth factor receptor
  • binding LCP2 (SLP676) to LAT (linker for activation of T cells)
  • binding to GAB1 (GRAB2-associated binding protein 1)
  • interacting with STAMBP
  • upon T cell activation, LAT is phosphorylated and associates with GRB2, GRAP2, and PLCG1 through its four distal tyrosine residues
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS