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FLASH GENE

Symbol

GRAP2

contributors: mct - updated : 30-08-2017

HGNC name	GRB2-related adaptor protein 2
HGNC id	4563

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.1      Physical location : 40.297.085 - 40.367.384
Synonym name	GRB2-related protein with insert domain
	growth factor receptor-bound protein 2-related adaptor protein 2
	SH3-SH2-SH3 adapter Mona
	hematopoietic cell-associated adaptor protein GRPL
	protein GADS
Synonym symbol(s)	GADS, GRID, MONA, GRBX, RP3-370M22.1, GRAP-2, GRB2L, GRBLG, GRPL, Grf40

DNA

TYPE	functioning gene
STRUCTURE	70.30 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004810 8 - 1552 NP_004801 - 330 thymus, spleen, tissues rich in leukocytes Qiu (1998)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage
cell lines	leukemia cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal SH3 domain followed by a SH2 domain
	an unique proline/glutamine-rich sequence od 120 AA between SH2 and the C terminal SH3 domain

HOMOLOGY

Homologene

FAMILY

GRB2/sem-5/DRK family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	coupling tyrosine kinase to the RAS pathway
	adaptor protein in the CD28 mediated costimulatory pathway in T cells
	recruiting cytosolic signal-transducing molecules to the activated receptor tyrosine kinases
	critical adaptor for CD3 signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	required for T cell development

PATHWAY

metabolism

signaling

signal transduction

LCP2/GRAP2/NCK1 adaptor protein pathway, implicated in regulation of the actin cytoskeleton by BCR-ABL kinase (Preisinger 2010)

a component

INTERACTION

DNA

RNA

small molecule

protein	CKIT
	EPOR binding
	CD28 and other signaling proteins, LCP2 like (SLP-76), GNB2L1 (RACK1), growth factor receptor
	binding LCP2 (SLP676) to LAT (linker for activation of T cells)
	binding to GAB1 (GRAB2-associated binding protein 1)
	interacting with STAMBP
	upon T cell activation, LAT is phosphorylated and associates with GRB2, GRAP2, and PLCG1 through its four distal tyrosine residues

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS