Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GRAP2 contributors: mct - updated : 30-08-2017
HGNC name GRB2-related adaptor protein 2
HGNC id 4563
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1552 - 330 thymus, spleen, tissues rich in leukocytes Qiu (1998)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines leukemia cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal SH3 domain followed by a SH2 domain
  • an unique proline/glutamine-rich sequence od 120 AA between SH2 and the C terminal SH3 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • GRB2/sem-5/DRK family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • coupling tyrosine kinase to the RAS pathway
  • adaptor protein in the CD28 mediated costimulatory pathway in T cells
  • recruiting cytosolic signal-transducing molecules to the activated receptor tyrosine kinases
  • critical adaptor for CD3 signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text required for T cell development
    PATHWAY
    metabolism
    signaling signal transduction
    LCP2/GRAP2/NCK1 adaptor protein pathway, implicated in regulation of the actin cytoskeleton by BCR-ABL kinase (Preisinger 2010)
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CKIT
  • EPOR binding
  • CD28 and other signaling proteins, LCP2 like (SLP-76), GNB2L1 (RACK1), growth factor receptor
  • binding LCP2 (SLP676) to LAT (linker for activation of T cells)
  • binding to GAB1 (GRAB2-associated binding protein 1)
  • interacting with STAMBP
  • upon T cell activation, LAT is phosphorylated and associates with GRB2, GRAP2, and PLCG1 through its four distal tyrosine residues
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS