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FLASH GENE
Symbol CHI3L2 contributors: mct - updated : 12-06-2015
HGNC name chitinase 3-like 2
HGNC id 1933
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung    
Skeletonappendicular skeletonjoint    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte Homo sapiens
not specificsynoviocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal sequence YKL, but lacking the active site glutamate essential for chitinase activity
  • a major (bta/alpha)8 triose-phosphate isomerase barrel domain and a small alpha + beta insertion domain
    • isoforms Precursor
    HOMOLOGY
    intraspecies homolog to YKL40
    Homologene
    FAMILY chitinase family of glycohydrolase, family-18 glycosyl hydrolases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having no chitotriosidase activity but a hydrolase activity
  • CHI3L1, CHI3L2 are involved in mediating the mitogenic response through the signal-regulated kinases ERK1/2
  • is a novel growth and differentiation factor involved in cartilage homeostasis
  • CHIA, CHIT1, CHI3L1, CHI3L2 and CHID1 exert important biological roles in the monocyte lineage and chronic inflammatory diseases
  • CHIA, CHI3L2 and CHID1 resulted unchanged during osteoclast differentiation, whereas CHIT1 and CHI3L1 increased significantly
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    CSF CHI3L2 levels were lower in progressive multiple sclerosis (MS) than in relapsing-remitting MS (RRMS) patients
    constitutional     --over  
    in osteoarthritic articular chondrocytes suggesting the involvement of CHI3L2 in the progression of osteoarthritis (OA)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential marker for the activation of chondrocytes and the progression of osteoarthritis
    • Therapy target
    ANIMAL & CELL MODELS