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FLASH GENE
Symbol CHI3L2 contributors: mct - updated : 12-06-2015
HGNC name chitinase 3-like 2
HGNC id 1933
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal sequence YKL, but lacking the active site glutamate essential for chitinase activity
  • a major (bta/alpha)8 triose-phosphate isomerase barrel domain and a small alpha + beta insertion domain
  • isoforms Precursor
    HOMOLOGY
    intraspecies homolog to YKL40
    Homologene
    FAMILY chitinase family of glycohydrolase, family-18 glycosyl hydrolases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having no chitotriosidase activity but a hydrolase activity
  • CHI3L1, CHI3L2 are involved in mediating the mitogenic response through the signal-regulated kinases ERK1/2
  • is a novel growth and differentiation factor involved in cartilage homeostasis
  • CHIA, CHIT1, CHI3L1, CHI3L2 and CHID1 exert important biological roles in the monocyte lineage and chronic inflammatory diseases
  • CHIA, CHI3L2 and CHID1 resulted unchanged during osteoclast differentiation, whereas CHIT1 and CHI3L1 increased significantly
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    CSF CHI3L2 levels were lower in progressive multiple sclerosis (MS) than in relapsing-remitting MS (RRMS) patients
    constitutional     --over  
    in osteoarthritic articular chondrocytes suggesting the involvement of CHI3L2 in the progression of osteoarthritis (OA)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential marker for the activation of chondrocytes and the progression of osteoarthritis
  • Therapy target
    ANIMAL & CELL MODELS