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FLASH GENE
Symbol CD164 contributors: npt/mct - updated : 24/10/2008
HGNC name CD164 antigen, sialomucin
HGNC id 1632
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
Endocrinethyroid    
Lymphoid/Immunethymus   highly
Reproductivefemale systembreastmammary gland highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage CD34+ B cell precursors and in maturing erythroid cells
cell lines colorectal and pancreatic adenocarcinoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular mucin domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cd164
    homolog to rattus endolyn
    Homologene
    FAMILY
  • CD164 family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text type I transmembrane protein
    basic FUNCTION
  • potent regulator of hematopoiesis
  • adhesion receptor that regulates the adhesion of CD34+ cells to bone marrow stroma
  • function as a receptor that regulates stem cell localization to the bone marrow
  • may participate in the localization of prostate cancer cells to the marrow and is further evidence that tumor metastasis and hematopoietic stem cell trafficking may involve similar processes
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text cell differentiation, identified by monoclonal antibodies 103B2/9E10 and 105A5
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein associates with CXCR4
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS