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FLASH GENE

Symbol

CD164

contributors: npt/mct - updated : 24/10/2008

HGNC name	CD164 antigen, sialomucin
HGNC id	1632

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q21      Physical location : 109.687.717 - 109.703.762
Synonym name	sialomucin
	cell differentiation antigen CD164,identigfied by monoclonal antibodies 103B2/9E10 and 105A5
	multi-glycosylated core protein 24
Synonym symbol(s)	MGC-24, MUC24, endolyn

DNA

TYPE	functioning gene
STRUCTURE	15.92 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CD164(E1-6) 6 - 3026 20 197 - Chan, Forde (2007) CD164 (E2) - splicing - - - - Chan CD164 (E3) - splicing - - - - Chan

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon     Endocrine thyroid         Lymphoid/Immune thymus       highly Reproductive female system breast mammary gland   highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage	CD34+ B cell precursors and in maturing erythroid cells
cell lines	colorectal and pancreatic adenocarcinoma cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two extracellular mucin domain

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Cd164
	homolog to rattus endolyn

Homologene

FAMILY

CD164 family

CATEGORY

adhesion , antigen , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
text	type I transmembrane protein

basic FUNCTION	potent regulator of hematopoiesis
	adhesion receptor that regulates the adhesion of CD34+ cells to bone marrow stroma
	function as a receptor that regulates stem cell localization to the bone marrow
	may participate in the localization of prostate cancer cells to the marrow and is further evidence that tumor metastasis and hematopoietic stem cell trafficking may involve similar processes

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

text	cell differentiation, identified by monoclonal antibodies 103B2/9E10 and 105A5

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

associates with CXCR4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS