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FLASH GENE
Symbol FKBP15 contributors: mct - updated : 23-04-2012
HGNC name FK506 binding protein 15, 133kDa
HGNC id 23397
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to YOTIAO
Homologene
FAMILY
  • FKBP-type PPIase family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • association to early endosomes via its central coiled-coil domain, and associated with both microtubules and the actin filament system, the two means of transport of early endosomes
    • basic FUNCTION
  • potentially involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement
  • may play an important role in endocytosis and subsequent membrane trafficking by interacting with AP2 through KIAA0196 and KIAA1033
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between FKBP15 and KIAA0196
  • FAM21C-tail also binds to FKBP15
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS