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FLASH GENE
Symbol FKBP15 contributors: mct - updated : 23-04-2012
HGNC name FK506 binding protein 15, 133kDa
HGNC id 23397
Location 9q32      Physical location : 115.927.799 - 115.983.641
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, related to YOTIAO
  • FK506-binding protein 15
  • peptidyl-prolyl cis-trans isomerase
  • 133 kDa FK506-binding protein
  • 133 kDa FKBP
  • protein phosphatase 1, regulatory subunit 76
  • WASP and FKBP-like
    • Synonym symbol(s) KIAA0674, PPIase, FKBP133, PPP1R76, WAFL
    EC.number 5.2.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 55.84 kb     28 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 4336 - 1219 - 2010 20376207
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to YOTIAO
    Homologene
    FAMILY
  • FKBP-type PPIase family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • association to early endosomes via its central coiled-coil domain, and associated with both microtubules and the actin filament system, the two means of transport of early endosomes
    • basic FUNCTION
  • potentially involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement
  • may play an important role in endocytosis and subsequent membrane trafficking by interacting with AP2 through KIAA0196 and KIAA1033
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between FKBP15 and KIAA0196
  • FAM21C-tail also binds to FKBP15
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS