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FLASH GENE
Symbol FKBP15 contributors: mct - updated : 23-04-2012
HGNC name FK506 binding protein 15, 133kDa
HGNC id 23397
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 4336 - 1219 - 2010 20376207
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to YOTIAO
Homologene
FAMILY
  • FKBP-type PPIase family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • association to early endosomes via its central coiled-coil domain, and associated with both microtubules and the actin filament system, the two means of transport of early endosomes
  • basic FUNCTION
  • potentially involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement
  • may play an important role in endocytosis and subsequent membrane trafficking by interacting with AP2 through KIAA0196 and KIAA1033
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between FKBP15 and KIAA0196
  • FAM21C-tail also binds to FKBP15
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS