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FLASH GENE

Symbol

CABIN1

contributors: mct/npt/pgu - updated : 09-06-2010

HGNC name	calcineurin binding protein 1
HGNC id	24187

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Lymphoid/Immune spleen         Nervous nerve cranial nerve     highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a leucine zipper
	a putative SH3 binding site
	three putative nuclear localization signals (NLS)
	several PEST sequences and phosphorylation sites
	additional calcineurin CN) binding domain in its 701-900 amino acid residues
	C-terminal CN binding region

HOMOLOGY

interspecies

homolog to murine procollagen alpha

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	transcriptional corepressor recruited by MEF2
	binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction
	recruiting chromatin-modifying enzymes, both histone deacetylases and a histone methyltransferase, to repress MEF2 transcriptional activity
	recruited to promoters through its interactions with DNA sequence-specific-binding protein MEF2
	implicated in regulation of neurotransmitter endocytosis in neuronal cells and muscle cell development
	recruiting SUV39H1 and repressing transcriptional activity
	inhibits TP53 function on chromatin in the quiescent state
	is a functional member of the human HUCA complex

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	apoptosis of T cells

PATHWAY

metabolism

signaling

signal transduction

a component

part of the quaternary HIRA/UBN1/CABIN1/ASF1A (HUCA) complex, assembled from recombinant proteins

INTERACTION

DNA	binding on the MEF2 target promoter in a calcium-dependent manner

RNA

small molecule

protein	binding to calmodulin which releases its association to MEF2, releasing of MEF2 and/or CABIN1, in a mutually exclusive manner
	interaction with a histone methyltransferase
	binding to SUV39H1
	bind directly to calcineurin (CN) using its C-terminal region and inhibit CN activity
	association with intracellular domains involved in GRM protein coupling provides an additional mechanism by which GRM5 endocytosis and signaling are regulated
	interacted with HIRA and their interaction domain was mapped to the C-terminal half of HIRA and the N-terminal part of CABIN1, and opposes MEF2- and HIRA-dependent transcription as assumed by its ability to tether repressive chromatin remodelers
	HIRA and CABIN1 interact at ectopic and endogenous levels of expression in cells

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS