Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CABIN1 contributors: mct/npt/pgu - updated : 09-06-2010
HGNC name calcineurin binding protein 1
HGNC id 24187
Location 22q11.23      Physical location : 24.407.764 - 24.574.596
Synonym name
  • similar to C. auratus neuropeptide Y
  • calcineurin inhibitor
    • Synonym symbol(s) KIAA0330, CAIN, PPP3IN
    DNA
    TYPE functioning gene
    STRUCTURE 166.83 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 7222 246 2220 - 2007 17172641
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunespleen    
    Nervousnervecranial nerve  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine zipper
  • a putative SH3 binding site
  • three putative nuclear localization signals (NLS)
  • several PEST sequences and phosphorylation sites
  • additional calcineurin CN) binding domain in its 701-900 amino acid residues
  • C-terminal CN binding region
    • HOMOLOGY
    interspecies homolog to murine procollagen alpha
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • transcriptional corepressor recruited by MEF2
  • binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction
  • recruiting chromatin-modifying enzymes, both histone deacetylases and a histone methyltransferase, to repress MEF2 transcriptional activity
  • recruited to promoters through its interactions with DNA sequence-specific-binding protein MEF2
  • implicated in regulation of neurotransmitter endocytosis in neuronal cells and muscle cell development
  • recruiting SUV39H1 and repressing transcriptional activity
  • inhibits TP53 function on chromatin in the quiescent state
  • is a functional member of the human HUCA complex
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text apoptosis of T cells
    PATHWAY
    metabolism
    signaling signal transduction
    a component part of the quaternary HIRA/UBN1/CABIN1/ASF1A (HUCA) complex, assembled from recombinant proteins
    INTERACTION
    DNA binding on the MEF2 target promoter in a calcium-dependent manner
    RNA
    small molecule
    protein
  • binding to calmodulin which releases its association to MEF2, releasing of MEF2 and/or CABIN1, in a mutually exclusive manner
  • interaction with a histone methyltransferase
  • binding to SUV39H1
  • bind directly to calcineurin (CN) using its C-terminal region and inhibit CN activity
  • association with intracellular domains involved in GRM protein coupling provides an additional mechanism by which GRM5 endocytosis and signaling are regulated
  • interacted with HIRA and their interaction domain was mapped to the C-terminal half of HIRA and the N-terminal part of CABIN1, and opposes MEF2- and HIRA-dependent transcription as assumed by its ability to tether repressive chromatin remodelers
  • HIRA and CABIN1 interact at ectopic and endogenous levels of expression in cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS