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FLASH GENE
Symbol MDN1 contributors: mct - updated : 16-02-2022
HGNC name MDN1, midasin homolog (yeast)
HGNC id 18302
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal AAA (ATPase associated with diverse cellular activities) ring, which, like dynein, has six ATPase sites
  • a C-terminal substrate-binding MIDAS domain , and MIDAS domain can form catch bonds with more than one UBL substrate
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae membrane protein YLR106
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • is a preribosomal factor that triggers an unknown maturation step in 60S subunit biogenesis
  • aligns with its interacting partners on the preribosome to effect a necessary step on the path to the export-competent 60S subunit
  • MDN1 AAA(+)-ATPase functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus
  • modification of PELP1 promotes the recruitment of MDN1 to pre-60S particles, while deSUMOylation is needed to release both MDN1 and PELP1 from pre-ribosomes
  • is an essential AAA (ATPase associated with various activities) protein that removes assembly factors from distinct precursors of the ribosomal 60S subunit
  • MKI67, GNL2, and MDN1 play an important role in organizing the RNAmetasome network
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS