Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MDN1 contributors: mct - updated : 16-02-2022
HGNC name MDN1, midasin homolog (yeast)
HGNC id 18302
Location 6q15      Physical location : 90.353.230 - 90.529.442
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, related to S cerevisiae membrane protein YLR106
  • MIDAS-containing protein
    • Synonym symbol(s) KIAA0301, DKFZp686H16106, FLJ23395, FLJ25587, FLJ42031, FLJ43191, REa1
    DNA
    TYPE functioning gene
    STRUCTURE 176.20 kb     102 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    102 - 18485 633 5596 - 2016 27814492
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal AAA (ATPase associated with diverse cellular activities) ring, which, like dynein, has six ATPase sites
  • a C-terminal substrate-binding MIDAS domain , and MIDAS domain can form catch bonds with more than one UBL substrate
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae membrane protein YLR106
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • is a preribosomal factor that triggers an unknown maturation step in 60S subunit biogenesis
  • aligns with its interacting partners on the preribosome to effect a necessary step on the path to the export-competent 60S subunit
  • MDN1 AAA(+)-ATPase functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus
  • modification of PELP1 promotes the recruitment of MDN1 to pre-60S particles, while deSUMOylation is needed to release both MDN1 and PELP1 from pre-ribosomes
  • is an essential AAA (ATPase associated with various activities) protein that removes assembly factors from distinct precursors of the ribosomal 60S subunit
  • MKI67, GNL2, and MDN1 play an important role in organizing the RNAmetasome network
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS