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FLASH GENE
Symbol MDN1 contributors: mct - updated : 16-02-2022
HGNC name MDN1, midasin homolog (yeast)
HGNC id 18302
DNA
TYPE functioning gene
STRUCTURE 176.20 kb     102 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
102 - 18485 633 5596 - 2016 27814492
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal AAA (ATPase associated with diverse cellular activities) ring, which, like dynein, has six ATPase sites
  • a C-terminal substrate-binding MIDAS domain , and MIDAS domain can form catch bonds with more than one UBL substrate
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae membrane protein YLR106
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • is a preribosomal factor that triggers an unknown maturation step in 60S subunit biogenesis
  • aligns with its interacting partners on the preribosome to effect a necessary step on the path to the export-competent 60S subunit
  • MDN1 AAA(+)-ATPase functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus
  • modification of PELP1 promotes the recruitment of MDN1 to pre-60S particles, while deSUMOylation is needed to release both MDN1 and PELP1 from pre-ribosomes
  • is an essential AAA (ATPase associated with various activities) protein that removes assembly factors from distinct precursors of the ribosomal 60S subunit
  • MKI67, GNL2, and MDN1 play an important role in organizing the RNAmetasome network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS