basic FUNCTION
| is a preribosomal factor that triggers an unknown maturation step in 60S subunit biogenesis |
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aligns with its interacting partners on the preribosome to effect a necessary step on the path to the export-competent 60S subunit |
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MDN1 AAA(+)-ATPase functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus |
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modification of PELP1 promotes the recruitment of MDN1 to pre-60S particles, while deSUMOylation is needed to release both MDN1 and PELP1 from pre-ribosomes |
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is an essential AAA (ATPase associated with various activities) protein that removes assembly factors from distinct precursors of the ribosomal 60S subunit |
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MKI67, GNL2, and MDN1 play an important role in organizing the RNAmetasome network |