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FLASH GENE
Symbol EPGN contributors: mct/npt - updated : 18/11/2008
HGNC name epithelial mitogen homolog (mouse)
HGNC id 17470
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus    
 liver    
Reproductivefemale systemuteruscervix  
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two hydrophobic regions, corresponding to a putative signal sequence and transmembrane domain
  • a core of amino acids encompassing six cysteine residues and two putative N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • EGF superfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • might represent the last EGF-like growth factor and define a category of low affinity ligands, whose bioactivity differs from the more extensively studied high affinity ligands
  • having ability to promote the growth of epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of ErbB receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS