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FLASH GENE
Symbol EPGN contributors: mct/npt - updated : 18/11/2008
HGNC name epithelial mitogen homolog (mouse)
HGNC id 17470
Location 4q13.3      Physical location : 75.174.203 - 75.179.306
Synonym name
  • epithelial mitogen
  • epigen
    • Synonym symbol(s) epigen, EPG, PRO9904, ALGV3072, FLJ75542
    DNA
    TYPE functioning gene
    STRUCTURE 5.10 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 847 14.7 133 - Kochupurakkal (2005)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus    
     liver    
    Reproductivefemale systemuteruscervix  
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two hydrophobic regions, corresponding to a putative signal sequence and transmembrane domain
  • a core of amino acids encompassing six cysteine residues and two putative N-linked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • EGF superfamily
    • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • might represent the last EGF-like growth factor and define a category of low affinity ligands, whose bioactivity differs from the more extensively studied high affinity ligands
  • having ability to promote the growth of epithelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of ErbB receptors
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS