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FLASH GENE
Symbol RNF138 contributors: mct/npt - updated : 21-05-2008
HGNC name ring finger protein 138
HGNC id 17765
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING finger domain
    • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having E3 ubiquitin ligase activity
  • nemo-like kinase (NLK)-associated ring finger protein that regulates the ubiquitylation and degradation of T
  • functioning as a novel ubiquitin-ligase to suppress the Wnt-beta-catenin signalingcell factor/lymphoid enhancer factor (TCF/LEF)
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS