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FLASH GENE
Symbol RNF138 contributors: mct/npt - updated : 21-05-2008
HGNC name ring finger protein 138
HGNC id 17765
Location 18q12.1      Physical location : 29.671.817 - 29.711.523
Synonym name
  • Nemo-like kinase-associated RING finger protein
  • E3 ubiquitin-protein ligase RNF138
    • Synonym symbol(s) HSD-4, STRIN, MGC8758, NARF
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 39.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 3566 28 245 - Saurin, Yamada (2006)
    5 splicing 2938 - 151 - Saurin, Yamada (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger domain
    • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having E3 ubiquitin ligase activity
  • nemo-like kinase (NLK)-associated ring finger protein that regulates the ubiquitylation and degradation of T
  • functioning as a novel ubiquitin-ligase to suppress the Wnt-beta-catenin signalingcell factor/lymphoid enhancer factor (TCF/LEF)
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS