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FLASH GENE

Symbol

IPO13

contributors: mct/pgu - updated : 25-11-2021

HGNC name	importin 13
HGNC id	16853

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       lowly Endocrine pancreas       lowly Nervous brain       predominantly Reproductive male system testis     highly Urinary kidney       lowly Visual eye anterior segment cornea   highly Mus musculus   eye lens       Mus musculus   eye retina       Mus musculus   eye sclera       Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

Text	lung, brain, heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to Drosophila CG7212

Homologene

FAMILY

importin-beta family of nuclear transport proteins

CATEGORY

transport carrier channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
	intracellular,nuclear envelope,pore

basic FUNCTION	acting as a mediator of nuclear import and export
	having functions in myopodin import and the regulation of these events is critical for normal and abnormal cellular differentiation
	mediates nuclear import of both histone fold heterodimers CHRAC-15/CHRAC-17 and p12/CHRAC-17
	unusual beta-karyopherin that is able to both import and export cargoes in and out of the nucleus
	mediates both, nuclear protein import and export
	role of IPO13 in eye morphogenesis
	can transport cargoes both into and out of the nucleus to contribute to a variety of important cellular processes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	protein-nucleus import, docking

PATHWAY

metabolism

signaling

a component

IPO13–UBE2I9 complex forms in the cytosol and translocates into the nucleus

INTERACTION

DNA

RNA

small molecule

protein	ARX interacting protein (interaction with the C-terminal of IPO13 nuclear localization sequences in the homeodomain of ARX is required for correct nuclear localization)
	in the cytoplasm, associates with different cargoes such UBE2I, and facilitates their import into the nucleus where RanGTP binding promotes the release of the cargo
	IPO13 may contribute to the pathogenesis of pterygium via modulation of KRT17 and JUN
	CTCF regulates the expression of IPO13, which, in turn, mediates the nuclear import of CTCF

cell & other

REGULATION

Other

IPO13 can be phosphorylated at Ser193 and this modification regulates IPO13 subcellular localization and nucleocytoplasmic transport function, with important implications for IPO13's role in development and other processes

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   significantly increased in the basal layer of the epithelium of the pterygium constitutional       loss of function could lead to ocular coloboma, microphthalmia, and cataract tumoral     --over   in endometriosis and endometrial carcinoma

Susceptibility

to airway hyperresponsiveness in asthmatic children

Variant & Polymorphism other	IPO13 variation is associated with improved airway hyperresponsiveness in asthmatic children

Candidate gene
Marker	can serve as an endometrial progenitor/stem cell marker
Therapy target

ANIMAL & CELL MODELS