Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | IPO13 | contributors: mct/pgu - updated : 25-11-2021 |
HGNC name | importin 13 |
HGNC id | 16853 |
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Location | 1p34.1 Physical location : 44.412.477 - 44.433.693 |
Synonym name | |
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Synonym symbol(s) | IMP13, RANBP13, KIAA0724, KAP13, LGL2 |
DNA |
TYPE | functioning gene |
STRUCTURE | 21.22 kb 20 Exon(s) |
Genomic sequence alignment details |
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10 Kb 5' upstream gene genomic sequence study |
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
Text | lung, brain, heart |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to Drosophila CG7212 |
Homologene |
FAMILY | importin-beta family of nuclear transport proteins |
CATEGORY | transport carrier channel |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm | |
intracellular,nucleus | |
intracellular,nuclear envelope,pore |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | cellular trafficking transport |
text | protein-nucleus import, docking |
PATHWAY |
metabolism |
signaling |
a component | IPO13–UBE2I9 complex forms in the cytosol and translocates into the nucleus |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Other | IPO13 can be phosphorylated at Ser193 and this modification regulates IPO13 subcellular localization and nucleocytoplasmic transport function, with important implications for IPO13's role in development and other processes |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility | to airway hyperresponsiveness in asthmatic children |
Variant & Polymorphism other | |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |