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FLASH GENE
Symbol IPO13 contributors: mct/pgu - updated : 25-11-2021
HGNC name importin 13
HGNC id 16853
Location 1p34.1      Physical location : 44.412.477 - 44.433.693
Synonym name
  • Ran binding protein 13
  • karyopherin 13
  • late gestation lung 2
  • Synonym symbol(s) IMP13, RANBP13, KIAA0724, KAP13, LGL2
    DNA
    TYPE functioning gene
    STRUCTURE 21.22 kb     20 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4041 108 963 - 2001 11447110
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
    Endocrinepancreas   lowly
    Nervousbrain   predominantly
    Reproductivemale systemtestis  highly
    Urinarykidney   lowly
    Visualeyeanterior segmentcornea highly Mus musculus
     eyelens    Mus musculus
     eyeretina    Mus musculus
     eyesclera    Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text lung, brain, heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG7212
    Homologene
    FAMILY importin-beta family of nuclear transport proteins
    CATEGORY transport carrier channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • acting as a mediator of nuclear import and export
  • having functions in myopodin import and the regulation of these events is critical for normal and abnormal cellular differentiation
  • mediates nuclear import of both histone fold heterodimers CHRAC-15/CHRAC-17 and p12/CHRAC-17
  • unusual beta-karyopherin that is able to both import and export cargoes in and out of the nucleus
  • mediates both, nuclear protein import and export
  • role of IPO13 in eye morphogenesis
  • can transport cargoes both into and out of the nucleus to contribute to a variety of important cellular processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein-nucleus import, docking
    PATHWAY
    metabolism
    signaling
    a component IPO13–UBE2I9 complex forms in the cytosol and translocates into the nucleus
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARX interacting protein (interaction with the C-terminal of IPO13 nuclear localization sequences in the homeodomain of ARX is required for correct nuclear localization)
  • in the cytoplasm, associates with different cargoes such UBE2I, and facilitates their import into the nucleus where RanGTP binding promotes the release of the cargo
  • IPO13 may contribute to the pathogenesis of pterygium via modulation of KRT17 and JUN
  • CTCF regulates the expression of IPO13, which, in turn, mediates the nuclear import of CTCF
  • cell & other
    REGULATION
    Other IPO13 can be phosphorylated at Ser193 and this modification regulates IPO13 subcellular localization and nucleocytoplasmic transport function, with important implications for IPO13's role in development and other processes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    significantly increased in the basal layer of the epithelium of the pterygium
    constitutional       loss of function
    could lead to ocular coloboma, microphthalmia, and cataract
    tumoral     --over  
    in endometriosis and endometrial carcinoma
    Susceptibility to airway hyperresponsiveness in asthmatic children
    Variant & Polymorphism other
  • IPO13 variation is associated with improved airway hyperresponsiveness in asthmatic children
  • Candidate gene
    Marker
  • can serve as an endometrial progenitor/stem cell marker
  • Therapy target
    ANIMAL & CELL MODELS